domingo, 26 de junho de 2011

Antioxidant supplementation for the treatment of acute lung injury: a meta-analysis


This meta-analysis was performed to evaluate the evidence  supporting  antioxidant supplementation as an adjunct therapy to prevent  oxidative damage  and  improve the clinical outcomes (mortality, length of hospital stay  and duration of mechanical ventilation).The  search strategy for  randomized controlled trials RCTs) involved the participation of two  researchers  who  independently assessed  the methodological quality of  each  full-text article  that was available  in  the PubMed,  ISI WEB of Knowledge and  ScienceDirect databases. We  extracted  110  studies from  the past  10 years, but  only 30  articles  met  the methodological criteria  (RCT,  blinded  and  statistically  significant results),  for a total of  241  animals  and 256  patients. This study found an odds ratio (OR) of 0.45 [95% confidence interval (CI): 0.26 to 0.79] for death in the experimental group compared with placebo (six trials, n = 256), an OR of 0.46 [95% CI:  0.26 to 0.87]  for  hospitalization time and an OR of 0.63 [95% CI: 0.35 to 1.12] for mechanical ventilation time between groups, Conflicting  evidence makes it impossible to recommend the routine use of antioxidant supplementation in critically ill patients.

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